Intravenous Administration of Nefopam Against Paracetamol as Postoperative Analgesia in Women Experiencing Repairs of Vaginal Wall Under Spinal Anesthesia: A Comparative Study

Abstract

Background: Pain is not always proportional to the magnitude of the surgical aggression to the tissues, as it is highly variable from one patient to another, and even around 10-15% of those operated on suffer no pain or only very mild pain. Thus, there is a more or less significant dissociation between nociception and pain, a well-known phenomenon in the case of chronic pain syndromes. Objective: To comparison the outcome of preventive administration of IV of Nefopam versus Paracetamol as postoperative analgesia in patients undergoing vaginal wall repairs under spinal anesthesia. Patients and method: A comparative study carried in our hospital during the period from the 1st of Jan 2020 to the end of Dec 2022, in which 90 patients were involved and divided in to three groups. Results: significant difference was found only after 6 and 9 hours post operatively (P<0.001) and no differences found in the rest of times, dose of analgesia by tramadol in one day duration show that significant decrease in N group than that in other two groups Conclusion: Intravenous Preventive administration of nefopam is effective for postoperative analgesic effect after spinal anesthesia in women undergoing vaginal repair than that occurred by IV Paracetamol.