Modern aspects of antimicrobial therapy in inflammatory processes of infectious nature

Abstract

The rational selection of antimicrobial agents for inflammatory diseases of infectious etiology remains one of the greatest challenges in medical practice due to the increasing resistance of pathogens. The aim of this study was to scientifically evaluate the efficacy of modern antimicrobial therapy regimens in the treatment of acute and chronic inflammation in various locations. The study included groups of patients with infectious and inflammatory processes who received empirical and etiological antibacterial therapy. The methodology included bacteriological analysis of biomaterial to determine the susceptibility of isolated strains to antibiotics, monitoring of the dynamics of inflammatory markers in blood, and evaluation of clinical recovery criteria. The study revealed a high prevalence of multidrug-resistant strains among the main pathogens, which reduces the efficacy of traditional initial regimens. The use of modern, stepped regimens and drugs with a high bioavailability profile has been shown to allow for the rapid suppression of the inflammatory response and minimize the risk of adverse reactions. This conclusion justifies the need for strict personalization of antimicrobial therapy, taking into account local levels of antibiotic resistance. It is recognized that the application of pharmacodynamic modeling principles and regular microbiological monitoring are essential for improving the efficacy of treatment for infectious and inflammatory diseases.