Proteinase-inhibitory system phenotypes and genotypes in occupational respiratory diseases

Abstract

Bronchopulmonary diseases caused by exposure to industrial aerosols remain one of the leading occupational health problems at the turn of the 20th and 21st centuries. Over the past five years, they have accounted for 33.6-36.1% of chronic occupational diseases in Russia, occupying a leading position. This is due to both the number of workers exposed to industrial aerosols and their high concentrations in the air of the workplace. The overwhelming majority of illnesses are associated with work in mining enterprises. It is in this sector of the national economy that working conditions are characterized by significantly exceeding hygienic standards for harmful factors. The continuous intensification of technological processes and the use of increasingly powerful mining equipment result in significant gross emissions of fine rock particles into the air of the workplace. The aim of this study is to investigate the impact of highly fibrogenic granite dust on workers, identify and substantiate risk factors for respiratory diseases, develop key principles for early diagnosis and prevention, and implement new methods for assessing professional suitability. The study identified and substantiated risk factors for respiratory diseases among granite production workers.