Physiological assessment of stress resistance in mental work

Abstract

Despite its long history, the study of bronchial asthma has not only retained its relevance in recent years but has also acquired new directions, emerging from the intersection of various fields of biomedical research. External factors in the workplace and environment influence metabolic adaptation processes that determine homeostasis. Therefore, in the context of chemicalization of the environment, it is of interest to study the influence of industrial chemical allergens on intracellular energy systems and individual components of neurohumoral regulation to assess the pathogenetic significance of non-immune mechanisms in the development of various forms of this pathology. Currently, interest has increased in studying biological defects at the subcellular level in patients with bronchial asthma to improve the effectiveness of early diagnosis, prevention, and treatment adjustments. Current understanding of the pathogenesis of bronchial asthma is based on the concept of defective β-adrenergic receptors, the biochemical substrate of which is the adenylate cyclase complex. In clinical practice, the phenotype of occupational asthma has been changing in recent decades. The aim of this study was to examine the adenylate cyclase and hypothalamic-pituitary systems in various forms of occupational asthma to expand our understanding of the role of non-immune mechanisms and their involvement in the pathogenesis of this condition. This is the first comprehensive study of adenylate cyclase and hypothalamic-pituitary system parameters in patients with occupational asthma with impaired prostaglandin metabolism.