Donation and autodonation in G-6-PD deficiency and heterozygous Nb-thalassemia

Abstract

Against a backdrop of increasing socioeconomic pressure, emotional and neuropsychic overload in the workplace contribute to stress and strain on physiological processes, with the nervous and cardiovascular systems among the first to respond. The work of law enforcement officers, related to the functioning of the law enforcement system and the exercise of their authority, is associated with prolonged neuroemotional stress. The latter, according to recommendations from the World Health Organization, is considered a risk factor for the development of work-related pathologies, primarily cardiovascular diseases. The need to maintain high professional performance and reliability of law enforcement officers under significant functional stress determines the importance and relevance of studying the body's responses, adaptation mechanisms, and their breakdowns in this category of workers. As is well known, the functioning of the neurohumoral system underlies these processes. The purpose of this study was to examine the state of neurohumoral regulation and the mechanisms underlying metabolic disorders to substantiate biochemical indicators for assessing them in workers with high levels of neuro-emotional stress. This is the first comprehensive study of neurohumoral regulation indicators, free radical oxidation activity, and metabolic processes in individuals with high levels of neuro-emotional stress.