Initial values of human chorionic gonadotropin as a prognosis of the evolution of pregnancy in assisted reproduction

Abstract

Monitoring early pregnancy after assisted reproductive technologies (ART) is crucial for the timely assessment of embryo viability. The aim of this study was to determine the prognostic value of baseline human chorionic gonadotropin (hCG) levels for evaluating the progression and outcome of pregnancies resulting from in vitro fertilization (IVF). A prospective study was conducted in a group of women who became pregnant after ART. The methodology included dynamic measurement of serum hCG concentrations on specific days after embryo transfer, as well as ultrasound monitoring of pregnancy progression. The study established clear threshold hormone levels that correlate with a favorable pregnancy course. Baseline values exceeding average statistical normative values were found to be highly accurate in predicting the development of a successful singleton or multiple pregnancy. Conversely, low baseline concentrations or insufficient growth were associated with a high risk of early reproductive loss, including missed miscarriages and ectopic pregnancies. The conclusion underlines that early quantitative determination of human chorionic gonadotropin serves as a reliable non-invasive marker, allowing for the earliest possible assessment of the biological potential of pregnancy and the timely adjustment of hormonal support strategies.